Unique features of different classes of G-protein-coupled receptors revealed from sequence coevolutionary and structural analysis.

ABSTRACT: G-protein-coupled receptors (GPCRs) are the largest family of human membrane proteins and represent the primary targets of about one third of currently marketed drugs. Despite the critical importance, experimental structures have been determined for only a limited portion of GPCRs and functional mechanisms of GPCRs remain poorly understood. Here, we have constructed novel sequence coevolutionary models of the A and B classes of GPCRs and compared them with residue contact frequency maps generated with available experimental structures. Significant portions of structural residue contacts were successfully detected in the sequence-based covariational models. "Exception" residue contacts predicted from sequence coevolutionary models but not available structures added missing links that were i

SUBMITTER: Do HN 

PROVIDER: S-EPMC8738117 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature