An expansion of the non-coding genome and its regulatory potential underlies vertebrate neuronal diversity.

ABSTRACT: Proper assembly and function of the nervous system requires the generation of a uniquely diverse population of neurons expressing a cell-type-specific combination of effector genes that collectively define neuronal morphology, connectivity, and function. How countless partially overlapping but cell-type-specific patterns of gene expression are controlled at the genomic level remains poorly understood. Here we show that neuronal genes are associated with highly complex gene regulatory systems composed of independent cell-type- and cell-stage-specific regulatory elements that reside in expanded non-coding genomic domains. Mapping enhancer-promoter interactions revealed that motor neuron enhancers are broadly distributed across the large chromatin domains. This distributed regulatory architec

SUBMITTER: Closser M 

PROVIDER: S-EPMC8738133 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature