Reduced frequency of cytotoxic CD56^dim CD16⁺ NK cells leads to impaired antibody-dependent degranulation in EBV-positive classical Hodgkin lymphoma.

ABSTRACT: Around 30-50% of classical Hodgkin lymphoma (cHL) cases in immunocompetent individuals from industrialized countries are associated with the B-lymphotropic Epstein-Barr virus (EBV). Although natural killer (NK) cells exhibit anti-viral and anti-tumoral functions, virtually nothing is known about quantitative and qualitative differences in NK cells in patients with EBV+ cHL vs. EBV- cHL. Here, we prospectively investigated 36 cHL patients without known immune suppression or overt immunodeficiency at diagnosis. All 10 EBV+ cHL patients and 25 out 26 EBV- cHL were seropositive for EBV antibodies, and EBV+ cHL patients presented with higher plasma EBV DNA levels compared to EBV- cHL patients. We show that the CD56^dim CD16⁺ NK cell subset was decreased in frequency in EBV+

SUBMITTER: Panisova E 

PROVIDER: S-EPMC8738354 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature