A systematic review of non-motor symptom evaluation in clinical trials for amyotrophic lateral sclerosis.

ABSTRACT:

Background

Amyotrophic lateral sclerosis (ALS) is increasingly recognised as a multi-system disorder, presenting with common and impactful non-motor symptoms, such as neuropsychiatric symtpoms, cognitive and behavioural changes, pain, disordered sleep, fatigue and problematic saliva.

Aim/hypothesis

We aimed to systematically review 25 years of ALS clinical trials data to identify if non-motor features were evaluated, in addition to the traditional measures of motor functioning and survival, and where evaluated to describe the instruments used to assess. We hypothesised that assessment of non-motor symptoms has been largely neglected in trial design and not evaluated with ALS-suitable instruments.

Methods

We reviewed clinical trials of investigative medicinal products

SUBMITTER: Beswick E 

PROVIDER: S-EPMC8738361 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature