Association of initial prednisolone dose with remission, relapse, and infectious complications in adult-onset minimal change disease.

ABSTRACT:

Background

A dose of 0.5-1 mg/kg/day of prednisolone (PSL) is administered for the initial treatment of minimal change disease (MCD). However, little is known about the optimal PSL dose for the initial treatment of MCD.

Methods

We conducted a retrospective multicenter cohort study of treatment-naive adult patients with MCD diagnosed by renal biopsy from 1981 to 2015 in whom PSL monotherapy was performed as the initial treatment. The exposure of interest was an initial median PSL dose of < 0.63 mg/kg/day (Group L) compared to ≥ 0.63 mg/kg/day (Group H). Cumulative remission and relapse after remission were compared between these groups using Cox regression adjusted for baseline characteristics.

Results

Ninety-one patients met the inclusion criteria. During a median fol

SUBMITTER: Tanabe K 

PROVIDER: S-EPMC8738364 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature