Bi-functional oxidized dextran-based hydrogel inducing microtumors: An in vitro three-dimensional lung tumor model for drug toxicity assays.

ABSTRACT: Cancer is a serious death causing disease having 8.2 million deaths in 2012. In the last decade, only about 10% of chemotherapeutic compounds showed productivity in drug screening. Two-dimensional culture assays are the most common in vitro drug screening models, which do not precisely model the in vivo condition for reliable preclinical drug screening. Three-dimensional scaffold-based cell cultures perhaps mimic tumor microenvironment and recapitulate physiologically more relevant tumor. This study was carried out to develop bi-functional oxidized dextran-based cell instructive hydrogel that provides three-dimensional environment to cancer cells for inducing microtumor. Oxidized dextran was blended with thiolated chitosan to fabricate an in situ self-gelable hydrogel (modified dextran-chi

SUBMITTER: Kedaria D 

PROVIDER: S-EPMC8738854 | biostudies-literature | 2017 Jan-Dec

REPOSITORIES: biostudies-literature