Analysis and identification of m⁶A RNA methylation regulators in metastatic osteosarcoma.

ABSTRACT: Osteosarcoma (OS) is characterized by rapid growth and early metastasis. However, its mechanism remains unclear. N⁶-methyladenosine (m⁶A) modification and its regulatory factors play essential roles in most cancers, including OS. In this study, we screened out 21 m⁶A modifiers using the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database, followed by the identification of the critical m⁶A methylation modifiers. The results revealed that the expression levels of three m⁶A methylation regulators, namely RBM15, METTL3, and LRPPRC, were associated with the low survival rate of patients with OS. We further studied the independent prognostic factors by performing univariate and multivariate Cox analyses and

SUBMITTER: Huang H 

PROVIDER: S-EPMC8738956 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature