Predictive value of different bilirubin subtypes for clinical outcomes in patients with acute ischemic stroke receiving thrombolysis therapy.

ABSTRACT:

Aims

To explore the association of total bilirubin (TBIL), direct bilirubin (DBIL), and indirect bilirubin (IBIL) levels with, as well as the incremental predictive value of different bilirubin subtypes for, poor outcomes in acute ischemic stroke patients after thrombolysis.

Methods

We analyzed 588 individuals out of 718 AIS participants, and all patients were followed up at 3 months after thrombolysis. The primary outcome was 3-month death and major disability (modified Rankin Scale (mRS) score of 3-6). The secondary outcomes were 3-month mortality (mRS score of 6), moderate-severe cerebral edema, and symptomatic intracranial hemorrhage (sICH), respectively.

Results

Elevated DBIL pre-thrombolysis was associated with an increased risk of primary outcome (OR 3.228; 95%

SUBMITTER: Peng Q 

PROVIDER: S-EPMC8739039 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature