Prostate tumor eccentricity predicts Gleason score better than prostate tumor volume.

ABSTRACT:

Background

Prostate tumor volume predicts biochemical recurrence, metastases, and tumor proliferation. A recent study showed that prostate tumor eccentricity (elongation or roundness) correlated with Gleason score. No studies examined the relationship among the prostate tumor's shape, volume, and potential aggressiveness.

Methods

Of the 26 patients that were analyzed, 18 had volumes >1 cc for the histology-based study, and 25 took up contrast material for the MRI portion of this study. This retrospective study quantitatively compared tumor eccentricity and volume measurements from pathology assessment sectioned wholemount prostates and multi-parametric MRI to Gleason scores. Multi-parametric MRI (T1, T2, diffusion, dynamic contrast-enhanced images) were resized, translated,

SUBMITTER: Mayer R 

PROVIDER: S-EPMC8739117 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature