Impact of point-spread function reconstruction on dynamic and static ¹⁸F-DOPA PET/CT quantitative parameters in glioma.

ABSTRACT:

Background

Quantification of dynamic and static parameters extracted from 3,4-dihydroxy-6-[¹⁸F]-fluoro-L-phenylalanine (¹⁸F-DOPA, FDOPA) positron emission tomography (PET)/computed tomography (CT) plays a critical role for glioma assessment. The objective of the present study was to investigate the impact of point-spread function (PSF) reconstruction on these quantitative parameters.

Methods

Fourteen patients with untreated gliomas and investigated with FDOPA PET/CT were analyzed. The distribution of the 14 cases was as follows: 6 astrocytomas-isocitrate dehydrogenase-mutant; 2 oligodendrogliomas/1p19q-codeleted-isocitrate dehydrogenase-mutant; and 6 isocitrate dehydrogenase-wild-type glioblastomas. A 0-20-min dynamic images (8×15, 2×30, 2×60, and 3×300

SUBMITTER: Girard A 

PROVIDER: S-EPMC8739156 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature