Biocompatibility and Application of Carbon Fibers in Heart Valve Tissue Engineering.

ABSTRACT: The success of tissue-engineered heart valves rely on a balance between polymer degradation, appropriate cell repopulation, and extracellular matrix (ECM) deposition, in order for the valves to continue their vital function. However, the process of remodeling is highly dynamic and species dependent. The carbon fibers have been well used in the construction industry for their high tensile strength and flexibility and, therefore, might be relevant to support tissue-engineered hearts valve during this transition in the mechanically demanding environment of the circulation. The aim of this study was to assess the suitability of the carbon fibers to be incorporated into tissue-engineered heart valves, with respect to optimizing their cellular interaction and mechanical flexibility during valve

SUBMITTER: Tseng YT 

PROVIDER: S-EPMC8739227 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature