General gene expression patterns and stemness of the gingiva and dental pulp.

ABSTRACT:

Background/purpose

Due to the unique properties of healing processes and cellular differentiation, the gingiva and dental pulp have attracted attention as a potential source of mesenchymal stem cells (MSCs). The purpose of this study was to obtain molecular-level information on these tissues in terms of their function and differentiation processes and investigate stemness.

Materials and methods

Healthy gingival tissues were collected from patients (n = 9; aged 7-12 years) who underwent simple surgical procedures, and normal dental pulp tissues were obtained from patients (n = 25; aged 11-25 years) undergoing tooth extraction for orthodontic reasons. Complementary DNA microarray, qRT-qPCR, and immunohistochemical staining were performed to assess general and MSC

SUBMITTER: Lee KE 

PROVIDER: S-EPMC8739237 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature