The additive effect of iloprost on the biological properties of Mineral trioxide aggregate on mesenchymal stem cells.

ABSTRACT:

Background/purpose

Iloprost has been proposed as a potential biomaterial owing to angiogenic and odontogenic properties. However, the liquid form can limit its use during clinical applications. Mineral trioxide aggregate (MTA) has been used for various dental applications in which cell-material interaction is essential. This study aimed to investigate additive effects of iloprost on the biological properties of MTA on the viability, attachment, migration and differentiation of human mesenchymal stem cells (hMSCs).

Materials and methods

Standardized human dentin disks were prepared. MTA was prepared by mixing distilled water or iloprost solution, and the lumen of the disks was filled with MTA or MTA-iloprost. hMSCs on disk alone and hMSCs on culture plates were used as contro

SUBMITTER: Almeshari A 

PROVIDER: S-EPMC8739256 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature