Systematic review and meta-analysis of genetic association studies of pelvic organ prolapse.

ABSTRACT:

Introduction and hypothesis

Family and twin studies demonstrate that pelvic organ prolapse (POP) is heritable, but the genetic etiology is poorly understood. This review aimed to identify genetic loci and specific polymorphisms associated with POP, while assessing the strength, consistency, and risk of bias among reported associations.

Methods

Updating an earlier systematic review, PubMed and HuGE Navigator as well as relevant conference abstracts were searched using genetic and phenotype keywords from 2015 to 2020. Screening and data extraction were performed in duplicate. Fixed and random effects meta-analyses were conducted using co-dominant models of inheritance. We assessed credibility of pooled associations using interim Venice criteria.

Results

We screened 504

SUBMITTER: Allen-Brady K 

PROVIDER: S-EPMC8739292 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature