Molecular Mechanisms Associated with Antidepressant Treatment on Major Depression.

ABSTRACT: Major depressive disorder (MDD) is a complex and multifactorial psychiatric disorder that causes serious health, social, and economic concerns worldwide. The main treatment of the symptoms is through antidepressant (AD) drugs. However, not all patients respond properly to these drugs. Omic sciences are widely used to analyze not only biomarkers for the AD response but also their molecular mechanism. In this review, we aimed to focus on omics data to better understand the molecular mechanisms involving AD effects on MDD. We consistently found, from preclinical to clinical data, that glutamatergic transmission, immune/inflammatory processes, energy metabolism, oxidative stress, and lipid metabolism were associated with traditional and potential new ADs. Despite efforts of studies investigati

SUBMITTER: Ramos-da-Silva L 

PROVIDER: S-EPMC8739385 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature