Exposure to silicates and systemic autoimmune-related outcomes in rodents: a systematic review.

ABSTRACT:

Background

Autoimmunity can result from the interplay between genetic background and effects of environmental and/or occupational exposure to hazardous materials. Several compounds, including silica dust, have been linked with systemic autoimmunity and systemic autoimmune diseases, based on epidemiological evidence. For asbestos, a strong link with systemic autoimmune diseases does not yet exist, however, several studies have documented features of autoimmunity following asbestos exposure. Even so, human studies are limited in their ability to identify and examine isolated exposures, making it difficult to demonstrate causation or to assess pathogenic mechanisms. Therefore, this systematic review examines the existing animal evidence regarding autoimmunity and exposure to silicates

SUBMITTER: Janssen LMF 

PROVIDER: S-EPMC8739508 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature