Mammalian splicing divergence is shaped by drift, buffering in trans, and a scaling law.

ABSTRACT: Alternative splicing is ubiquitous, but the mechanisms underlying its pattern of evolutionary divergence across mammalian tissues are still underexplored. Here, we investigated the cis-regulatory divergences and their relationship with tissue-dependent trans-regulation in multiple tissues of an F1 hybrid between two mouse species. Large splicing changes between tissues are highly conserved and likely reflect functional tissue-dependent regulation. In particular, micro-exons frequently exhibit this pattern with high inclusion levels in the brain. Cis-divergence of splicing appears to be largely non-adaptive. Although divergence is in general associated with higher densities of sequence variants in regulatory regions, events with high usage of the dominant isoform appare

SUBMITTER: Zou X 

PROVIDER: S-EPMC8739531 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature