Genome-wide gene-air pollution interaction analysis of lung function in 300,000 individuals.

ABSTRACT:

Background

Impaired lung function is predictive of mortality and is a key component of chronic obstructive pulmonary disease. Lung function has a strong genetic component but is also affected by environmental factors such as increased exposure to air pollution, but the effect of their interactions is not well understood.

Objectives

To identify interactions between genetic variants and air pollution measures which affect COPD risk and lung function. Additionally, to determine whether previously identified lung function genetic association signals showed evidence of interaction with air pollution, considering both individual effects and combined effects using a genetic risk score (GRS).

Methods

We conducted a genome-wide gene-air pollution interaction analysis of spirom

SUBMITTER: Melbourne CA 

PROVIDER: S-EPMC8739564 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature