The prognosis biomarkers based on m6A-related lncRNAs for myeloid leukemia patients.

ABSTRACT:

Background

Chronic myeloid leukemia (CML) and acute myeloid leukemia (AML) are two common malignant disorders in leukemia. Although potent drugs are emerging, CML and AML may still relapse after the drug treatment is stopped. N6-methyladenosine (m6A) and lncRNAs play certain roles in the occurrence and development of tumors, but m6A-modified LncRNAs in ML remain to be further investigated.

Methods

In this study, we extracted and analyzed the TCGA gene expression profile of 151 ML patients and the clinical data. On this basis, we then evaluated the immune infiltration capacity of ML and LASSO-penalized Cox analysis was applied to construct the prognostic model based on m6A related lncRNAs to verify the prognostic risk in clinical features of ML. Quantitative reverse transcrip

SUBMITTER: Yang LR 

PROVIDER: S-EPMC8739709 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature