Liquid Chromatography-Electron Capture Negative Ionization-Tandem Mass Spectrometry Detection of Pesticides in a Commercial Formulation.

ABSTRACT: Negative chemical ionization (NCI) and electron-capture negative ionization (ECNI) are gas chromatography-mass spectrometry (GC-MS) techniques that generate negative ions in the gas phase for compounds containing electronegative atoms or functional groups. In ECNI, gas-phase thermal electrons can be transferred to electrophilic substances to produce M^-• ions and scarce fragmentation. As a result of the electrophilicity requirements, ECNI is characterized by high-specificity and low background noise, generally lower than EI, offering lower detection limits. The aim of this work is to explore the possibility of extending typical advantages of ECNI to liquid chromatography-mass spectrometry (LC-MS). The LC is combined with the novel liquid-EI (LEI) LC-EIMS interface, the eluent is

SUBMITTER: Cappiello A 

PROVIDER: S-EPMC8739837 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature