Deinococcus radiodurans Exopolysaccharide Inhibits Staphylococcus aureus Biofilm Formation.

ABSTRACT: Deinococcus radiodurans is an extremely resistant bacterium against extracellular stress owing to on its unique physiological functions and the structure of its cellular constituents. Interestingly, it has been reported that the pattern of alteration in Deinococcus proportion on the skin is negatively correlated with skin inflammatory diseases, whereas the proportion of Staphylococcus aureus was increased in patients with chronic skin inflammatory diseases. However, the biological mechanisms of deinococcal interactions with other skin commensal bacteria have not been studied. In this study, we hypothesized that deinococcal cellular constituents play a pivotal role in preventing S. aureus colonization by inhibiting biofilm formation. To prove this, we first isola

SUBMITTER: Chen F 

PROVIDER: S-EPMC8739996 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature