Effect of Metformin on Testosterone Levels in Male Patients With Type 2 Diabetes Mellitus Treated With Insulin.

ABSTRACT:

Aim

To explore the chronic effects of metformin on testosterone levels in men with type 2 diabetes mellitus (T2DM).

Methods

This is a secondary analysis of a real-world study evaluating the efficacy and safety of premixed insulin treatment in patients with T2DM via 3-month intermittent flash glucose monitoring. Male patients aged 18-60 who were using metformin during the 3-month study period were included as the metformin group. The control group included males without metformin therapy by propensity score matching analysis with age as a covariate. Testosterone levels were measured at baseline and after 3-month treatment.

Results

After 3-month treatment, the control group had higher levels of total testosterone, free and bioavailable testosterone than those at

SUBMITTER: Cai T 

PROVIDER: S-EPMC8740051 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature