Serum and urine profiles of TGF-β superfamily members in reproductive aged women.

ABSTRACT:

Background

TGF-β superfamily members are important biomarkers of reproductive health in women desiring fertility and during pregnancy. TGF-β proteins derived from the ovary and/or placenta have been detected in serum in women, but there have been very few attempts to measure them non-invasively, such as in urinary samples, and to compare them to serum concentrations.

Methods

We measured inhibin A, inhibin B, total inhibin, AMH, activin A, activin B, activin AB, follistatin, the GDF-9/BMP-15 complex, and GDF-15 in paired serum and urine samples from healthy reproductive aged women and in pregnant (second trimester) women.

Results

We detected all hormones in serum in both pregnant and non-pregnant women. Inhibin A, total inhibin, activin A, activin AB, follistatin, and

SUBMITTER: Calvert ME 

PROVIDER: S-EPMC8740174 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature