New approach for genomic characterisation of equine sarcoid-derived BPV-1/-2 using nanopore-based sequencing.

ABSTRACT:

Background

Bovine papillomavirus (BPV) types 1 and 2 play a central role in the etiology of the most common neoplasm in horses, the equine sarcoid. The unknown mechanism behind the unique variety in clinical presentation on the one hand and the host dependent clinical outcome of BPV-1 infection on the other hand indicate the involvement of additional factors. Earlier studies have reported the potential functional significance of intratypic sequence variants, along with the existence of sarcoid-sourced BPV variants. Therefore, intratypic sequence variation seems to be an important emerging viral factor. This study aimed to give a broad insight in sarcoid-sourced BPV variation and explore its potential association with disease presentation.

Methods

In order to do this, a nanop

SUBMITTER: Gysens L 

PROVIDER: S-EPMC8740336 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature