Serum short-chain fatty acids and its correlation with motor and non-motor symptoms in Parkinson's disease patients.

ABSTRACT:

Background

Parkinson's disease (PD) is associated with enteric nervous system dysfunction and gut microbiota dysbiosis. Short-chain fatty acids (SCFAs), derived from gut microbiota, are supposed to anticipate PD pathogenesis via the pathway of spinal cord and vagal nerve or the circulatory system. However, the serum concentration of SCFAs in PD patients is poorly known. This study aims to investigate the exact level of SCFAs in PD patients and its correlation with Parkinson's symptoms.

Methods

50 PD patients and 50 healthy controls were recruited, and their demographic and clinical characteristics were collected. The serum concentration of SCFAs was detected using a gas chromatography-mass spectrometer. SCFAs were compared between PD and control groups. The correlation betwe

SUBMITTER: Wu G 

PROVIDER: S-EPMC8740341 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature