Exposure to environmentally relevant concentrations of ambient fine particulate matter (PM_2.5) depletes the ovarian follicle reserve and causes sex-dependent cardiovascular changes in apolipoprotein E null mice.

ABSTRACT:

Background

Fine particulate matter (PM_2.5) exposure accelerates atherosclerosis and contains known ovotoxic chemicals. However, effects of exposure to PM_2.5 on the finite ovarian follicle pool have hardly been investigated, nor have interactions between ovarian and cardiovascular effects. We hypothesized that subchronic inhalation exposure to human-relevant concentrations of PM_2.5 results in destruction of ovarian follicles via apoptosis induction, as well as accelerated recruitment of primordial follicles into the growing pool. Further, we hypothesized that destruction of ovarian follicles enhances the adverse cardiovascular effects of PM_2.5 in females.

Results

Hyperlipidemic apolipoprotein E (Apoe) null ovary-intact or ovariectom

SUBMITTER: Luderer U 

PROVIDER: S-EPMC8740366 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature