Hydrogel composite scaffolds achieve recruitment and chondrogenesis in cartilage tissue engineering applications.

ABSTRACT:

Background

The regeneration and repair of articular cartilage remains a major challenge for clinicians and scientists due to the poor intrinsic healing of this tissue. Since cartilage injuries are often clinically irregular, tissue-engineered scaffolds that can be easily molded to fill cartilage defects of any shape that fit tightly into the host cartilage are needed.

Method

In this study, bone marrow mesenchymal stem cell (BMSC) affinity peptide sequence PFSSTKT (PFS)-modified chondrocyte extracellular matrix (ECM) particles combined with GelMA hydrogel were constructed.

Results

In vitro experiments showed that the pore size and porosity of the solid-supported composite scaffolds were appropriate and that the scaffolds provided a three-dimensional microenvironment su

SUBMITTER: Huang B 

PROVIDER: S-EPMC8740469 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature