A novel prognostic index for sporadic Burkitt lymphoma in adult patients: a real-word multicenter study.

ABSTRACT:

Background

Adult sporadic Burkitt lymphoma (BL) is a rare but highly aggressive subtype of lymphoma which lacks its own unique prognostic model. Systemic inflammatory biomarkers have been confirmed as prognostic markers in several types of malignancy. Our objective was to explore the predictive value of pretreatment inflammatory biomarkers and establish a novel, clinically applicable prognostic index for adult patients with sporadic BL.

Methods

We surveyed retrospectively 336 adult patients with newly diagnosed sporadic BL at 8 Chinese medical centers and divided into training cohort (n = 229) and validation cohort (n = 107). The pretreatment inflammatory biomarkers were calculated for optimal cut-off value. The association between serum biomarkers and overall survival (OS)

SUBMITTER: Chen MT 

PROVIDER: S-EPMC8740497 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature