Metabolomics of a cell line-derived xenograft model reveals circulating metabolic signatures for malignant mesothelioma.

ABSTRACT:

Background

Malignant mesothelioma (MM) is a rare and highly aggressive cancer. Despite advances in multidisciplinary treatments for cancer, the prognosis for MM remains poor with no effective diagnostic biomarkers currently available. The aim of this study was to identify plasma metabolic biomarkers for better MM diagnosis and prognosis by use of a MM cell line-derived xenograft (CDX) model.

Methods

The MM CDX model was confirmed by hematoxylin and eosin staining and immunohistochemistry. Twenty female nude mice were randomly divided into two groups, 10 for the MM CDX model and 10 controls. Plasma samples were collected two weeks after tumor cell implantation. Gas chromatography-mass spectrometry analysis was conducted. Both univariate and multivariate statistics were used t

SUBMITTER: Gao Y 

PROVIDER: S-EPMC8740518 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature