Decreased Choroidal Blood Perfusion Induces Myopia in Guinea Pigs.

ABSTRACT:

Purpose

The development of myopia in guinea pigs can be inhibited by attenuating scleral hypoxia by increasing choroidal blood perfusion (ChBP). In this study, we reduced ChBP through surgical and pharmacological methods to determine the effect on myopia development. We also determined whether ChBP was reduced by quinpirole, a drug that enhances form-deprivation myopia (FDM).

Methods

ChBP was reduced in the right eyes of guinea pigs via transection of the temporal ciliary arteries or daily injections of phenylephrine into the inferior peribulbar space for one week during normal ocular growth. Other guinea pigs were subjected to two weeks of monocular FDM-with facemasks, along with daily injections of quinpirole, a dopamine D2 receptor agonist, to enhance the FDM. Changes in

SUBMITTER: Zhou X 

PROVIDER: S-EPMC8740532 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature