Match_Motif: A rapid computational tool to assist in protein-protein interaction design.

ABSTRACT: In order to generate protein assemblies with a desired function, the rational design of protein-protein binding interfaces is of significant interest. Approaches based on random mutagenesis or directed evolution may involve complex experimental selection procedures. Also, molecular modeling approaches to design entirely new proteins and interactions with partner molecules can involve large computational efforts and screening steps. In order to simplify at least the initial effort for designing a putative binding interface between two proteins the Match_Motif approach has been developed. It employs the large collection of known protein-protein complex structures to suggest interface modifications that may lead to improved binding for a desired input interaction geometry. The approach extrac

SUBMITTER: Zacharias M 

PROVIDER: S-EPMC8740833 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature