Saline Compared to Balanced Crystalloid in Patients With Diabetic Ketoacidosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

ABSTRACT:

Objectives

This systematic review and meta-analysis compared the use of saline to balanced crystalloid for fluid resuscitation in patients with diabetic ketoacidosis (DKA).

Data sources

We searched databases including Medline, Embase, and the Cochrane registry.

Study selection

We included randomized controlled trials (RCTs) that compared saline to balanced crystalloid in patients with DKA.

Data extraction

We pooled estimates of effect using relative risk for dichotomous outcomes and mean differences (MDs) for continuous outcomes, both with 95% CIs. We assessed risk of bias for included RCTs using the modified Cochrane tool and certainty of evidence using Grading of Recommendations, Assessment, Development, and Evaluation methodology.

Data synthesis

We in

SUBMITTER: Alghamdi NA 

PROVIDER: S-EPMC8740878 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature