Comparison of Equations To Estimate Glomerular Filtration Rate and Their Impact on Frequency of Cisplatin-associated Acute Kidney Injury.

ABSTRACT:

Background

Accurate estimation of kidney function is essential for patient selection and drug dosing in patients with cancer. eGFR equations are necessary for decision making and monitoring. Our aim was to identify which of these equations-estimated creatinine clearance (eCrCl) by Cockcroft-Gault (CG), eGFR by Modification of Diet in Renal Disease (eGFR_MDRD), CKD Epidemiology Collaboration (eGFR_CKD-EPI) or the recently proposed Janowitz-Williams equation (eGFR_J-W)-would be most suitable for GFR estimation among patients with cancer receiving cisplatin.

Methods

We assembled a cohort of 5274 patients with cancer treated with cisplatin-based chemotherapy at two large cancer centers. We ascertained the frequency of cisplatin-associated AKI (C-AKI

SUBMITTER: Motwani SS 

PROVIDER: S-EPMC8741004 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature