Establishing laboratory-specific reference intervals for TSH and fT4 by use of the indirect Hoffman method.

ABSTRACT:

Background

The results of examinations of laboratory parameters are the basis of appropriate medical decisions. The availability of reliable and accurate reference intervals (RIs) for each laboratory parameter is an integral part of its appropriate interpretation. Each medical laboratory should confirm their RIs. Up-to-date reference intervals for thyroid function hormones are still a matter of ongoing controversy. The aim of the study was the application of the indirect Hoffman method to determine RIs for TSH and fT4 based on the large data pools stored in laboratory information systems and the comparison of these RIs to generally used RIs.

Material and methods

The TSH and fT4 routine examination results of hospitalized and outpatient populations were collected over five ye

SUBMITTER: Placzkowska S 

PROVIDER: S-EPMC8741008 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature