Evolution of protection after maternal immunization for respiratory syncytial virus in cotton rats.

ABSTRACT: Maternal anti-respiratory syncytial virus (RSV) antibodies acquired by the fetus through the placenta protect neonates from RSV disease through the first weeks of life. In the cotton rat model of RSV infections, we previously reported that immunization of dams during pregnancy with virus-like particles assembled with mutation stabilized pre-fusion F protein as well as the wild type G protein resulted in robust protection of their offspring from RSV challenge. Here we describe the durability of those protective responses in dams, the durability of protection in offspring, and the transfer of that protection to offspring of two consecutive pregnancies without a second boost immunization. We report that four weeks after birth, offspring of the first pregnancy were significantly protected from

SUBMITTER: Blanco JCG 

PROVIDER: S-EPMC8741018 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature