Pre-Digested Protein Enteral Nutritional Supplementation Enhances Recovery of CD4⁺ T Cells and Repair of Intestinal Barrier in HIV-Infected Immunological Non-Responders.

ABSTRACT: AIDS patients with immune non-response are prone to malnutrition, intestinal barrier damage, thus aggravating chronic immune activation and inflammation. However, nutritional interventions targeting malnutrition may be beneficial to restore immune function, improve clinical outcomes, and reduce mortality remains largely unclear. This work aimed to evaluate the efficacy of a nutritional supplement in HIV-infected immune non-responders (INRs). The subjects received oral supplementation of a pre-digested protein nutrition formula for three months. We show that the CD4⁺ T and CD8⁺ T cell counts were significantly increased after supplementation of the pre-digested enteral nutritional supplement. Among all pro-inflammatory cytokines in the serum, only IL-1β level was signi

SUBMITTER: Geng ST 

PROVIDER: S-EPMC8741150 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature