A lethal mouse model for evaluating vaccine-associated enhanced respiratory disease during SARS-CoV-2 infection.
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ABSTRACT:
SUBMITTER: Iwata-Yoshikawa N
PROVIDER: S-EPMC8741184 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
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A lethal mouse model for evaluating vaccine-associated enhanced respiratory disease during SARS-CoV-2 infection.
Iwata-Yoshikawa Naoko N Shiwa Nozomi N Sekizuka Tsuyoshi T Sano Kaori K Ainai Akira A Hemmi Takuya T Kataoka Michiyo M Kuroda Makoto M Hasegawa Hideki H Suzuki Tadaki T Nagata Noriyo N
Science advances 20220107 1
One safety concern during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine development has been the vaccine-associated enhanced disease, which is characterized by eosinophilic immunopathology and T helper cell type 2 (T<sub>H</sub>2)–biased immune responses with insufficient neutralizing antibodies. In this study, we established a lethal animal model using BALB/c mice and a mouse-passaged isolate (QHmusX) from a European lineage of SARS-CoV-2. The QHmusX strain induced acute ...[more]
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