Human B cell lineages associated with germinal centers following influenza vaccination are measurably evolving.

ABSTRACT: The poor efficacy of seasonal influenza virus vaccines is often attributed to pre-existing immunity interfering with the persistence and maturation of vaccine-induced B cell responses. We previously showed that a subset of vaccine-induced B cell lineages are recruited into germinal centers (GCs) following vaccination, suggesting that affinity maturation of these lineages against vaccine antigens can occur. However, it remains to be determined whether seasonal influenza vaccination stimulates additional evolution of vaccine-specific lineages, and previous work has found no significant increase in somatic hypermutation among influenza-binding lineages sampled from the blood following seasonal vaccination in humans. Here, we investigate this issue using a phylogenetic test of measurable immun

SUBMITTER: Hoehn KB 

PROVIDER: S-EPMC8741214 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature