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Two novel human coronavirus OC43 genotypes circulating in hospitalized children with pneumonia in China.

ABSTRACT: HCoV-OC43 is one of the mildly pathogenic coronaviruses with high infection rates in common population. Here, 43 HCoV-OC43 related cases with pneumonia were reported, corresponding genomes of HCoV-OC43 were obtained. Phylogenetic analyses based on complete genome, orf1ab and spike genes revealed that two novel genotypes of HCoV-OC43 have emerged in China. Obvious recombinant events also can be detected in the analysis of the evolutionary dynamics of novel HCoV-OC43 genotypes. Estimated divergence time analysis indicated that the two novel genotypes had apparently independent evolutionary routes. Efforts should be conducted for further investigation of genomic diversity and evolution analysis of mildly pathogenic coronaviruses.

SUBMITTER: Zhang Z

PROVIDER: S-EPMC8741245 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Two novel human coronavirus OC43 genotypes circulating in hospitalized children with pneumonia in China.

Zhang Zhaoyong Z Liu Wenkuan W Zhang Shengnan S Wei Peilan P Zhang Lu L Chen Dehui D Qiu Shuyan S Li Xiaobo X Zhao Jingxian J Shi Yongxia Y Zhou Rong R Wang Yanqun Y Zhao Jincun J

Emerging microbes & infections 20221201 1

HCoV-OC43 is one of the mildly pathogenic coronaviruses with high infection rates in common population. Here, 43 HCoV-OC43 related cases with pneumonia were reported, corresponding genomes of HCoV-OC43 were obtained. Phylogenetic analyses based on complete genome, orf1ab and spike genes revealed that two novel genotypes of HCoV-OC43 have emerged in China. Obvious recombinant events also can be detected in the analysis of the evolutionary dynamics of novel HCoV-OC43 genotypes. Estimated divergenc ...[more]

PMID: 34907853

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2018-03-21 | GSE103842 | GEO

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