Gut microbiota-motility interregulation: insights from in vivo, ex vivo and in silico studies.

ABSTRACT: The human gastrointestinal tract is home to trillions of microbes. Gut microbial communities have a significant regulatory role in the intestinal physiology, such as gut motility. Microbial effect on gut motility is often evoked by bioactive molecules from various sources, including microbial break down of carbohydrates, fibers or proteins. In turn, gut motility regulates the colonization within the microbial ecosystem. However, the underlying mechanisms of such regulation remain obscure. Deciphering the inter-regulatory mechanisms of the microbiota and bowel function is crucial for the prevention and treatment of gut dysmotility, a comorbidity associated with many diseases. In this review, we present an overview of the current knowledge on the impact of gut microbiota and its products on

SUBMITTER: Waclawikova B 

PROVIDER: S-EPMC8741295 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature