Quercetin Relieves the Excised Great Saphenous Vein Oxidative Damage and Inflammatory Reaction.

ABSTRACT:

Objective

The patency and quality of transplanted great saphenous vein (GSV) can seriously influence the physical state and life quality of patients who accepted the coronary artery bypass grafting (CABG). Quercetin is known for antioxidant, antithrombotic, anti-inflammatory, and antitumor properties. In this study, we examined the protection of quercetin to the great saphenous vein from oxidative and inflammatory damage.

Methods

The GSVs were collected from 15 patients undergoing CABG and cultured. Treated the veins by H₂O₂ and detected the NO, SOD, and MDA content by the relevant kits to explore the quercetin protection against oxidative damage. Then, for another group of GSVs, sheared them and detected the inflammatory cytokines, such as IL-6, TNF

SUBMITTER: Bai Y 

PROVIDER: S-EPMC8741364 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature