Association of MHCY genotypes in lines of chickens divergently selected for high or low antibody response to sheep red blood cells.

ABSTRACT: The chicken MHCY region contains members of several gene families including a family of highly polymorphic MHC class I genes that are structurally distinct from their classical class I gene counterparts. Genetic variability at MHCY could impart variability in immune responses, but robust tests for whether or not this occurs have been lacking. Here we defined the MHCY genotypes present in 2 sets of chicken lines selected for high or low antibody response, the Virginia Tech (VT) HAS and LAS, and the Wageningen University (WU) HA and LA lines. Both sets were developed under long-term bidirectional selection for differences in antibody responses following immunization with the experimental antigen sheep red blood cells. Lines in which selection was relaxed (VT HAR and LAR) or lacking (WU C) pr

SUBMITTER: Zhang J 

PROVIDER: S-EPMC8741507 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature