R2* relaxometry analysis for mapping of white matter alteration in Parkinson's disease with mild cognitive impairment.

ABSTRACT:

Background

R2* relaxometry analysis combined with quantitative susceptibility mapping (QSM), which has high sensitivity to iron deposition, can distinguish microstructural changes of the white matter (WM) and iron deposition, thereby providing a sensitive and biologically specific measure of the WM owing to the changes in myelin and its surrounding environment. This study aimed to explore the microstructural WM alterations associated with cognitive impairment in patients with Parkinson's disease (PD) using R2* relaxometry analysis combined with QSM.

Materials and methods

We enrolled 24 patients with PD and mild cognitive impairment (PD-MCI), 22 patients with PD and normal cognition (PD-CN), and 19 age- and sex-matched healthy controls (HC). All participants underwent Montrea

SUBMITTER: Kan H 

PROVIDER: S-EPMC8741619 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature