Activated but functionally impaired memory Tregs are expanded in slow progressors to type 1 diabetes.

ABSTRACT:

Aims/hypothesis

Slow progressors to type 1 diabetes are individuals positive for multiple pancreatic islet autoantibodies who have remained diabetes-free for at least 10 years; regulation of the autoimmune response is understudied in this group. Here, we profile CD4⁺ regulatory T cells (Tregs) in a small but well-characterised cohort of extreme slow progressors with a median age 43 (range 31-72 years), followed up for 18-32 years.

Methods

Peripheral blood samples were obtained from slow progressors (n = 8), age- and sex-matched to healthy donors. One participant in this study was identified with a raised HbA_1c at the time of assessment and subsequently diagnosed with diabetes; this donor was individually evaluated in the analysis of the data. Peripheral

SUBMITTER: Boldison J 

PROVIDER: S-EPMC8741669 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature