Collision Cross Sections for Native Proteomics: Challenges and Opportunities.

ABSTRACT: Recent advancements place a comprehensive catalog of protein structure, oligomeric state, sequence, and modification status tentatively within reach, thus providing an unprecedented roadmap to therapies for many human diseases. To achieve this goal, revolutionary technologies capable of bridging key gaps in our ability to simultaneously measure protein composition and structure must be developed. Much of the current progress in this area has been catalyzed by mass spectrometry (MS) tools, which have become an indispensable resource for interrogating the structural proteome. For example, methods associated with native proteomics seek to comprehensively capture and quantify the endogenous assembly states for all proteins within an organism. Such technologies have often been partnered with io

SUBMITTER: Ruotolo BT 

PROVIDER: S-EPMC8741738 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature