BDNF Val66Met gene polymorphism modulates brain activity following rTMS-induced memory impairment.

ABSTRACT: The BDNF Val66Met gene polymorphism is a relevant factor explaining inter-individual differences to TMS responses in studies of the motor system. However, whether this variant also contributes to TMS-induced memory effects, as well as their underlying brain mechanisms, remains unexplored. In this investigation, we applied rTMS during encoding of a visual memory task either over the left frontal cortex (LFC; experimental condition) or the cranial vertex (control condition). Subsequently, individuals underwent a recognition memory phase during a functional MRI acquisition. We included 43 young volunteers and classified them as 19 Met allele carriers and 24 as Val/Val individuals. The results revealed that rTMS delivered over LFC compared to vertex stimulation resulted in reduced memory perfo

SUBMITTER: Abellaneda-Perez K 

PROVIDER: S-EPMC8741781 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature