Interrelationship between 2019-nCov receptor DPP4 and diabetes mellitus targets based on protein interaction network.

ABSTRACT: Patients with diabetes are more likely to be infected with Coronavirus disease 2019 (COVID-19), and the risk of death is significantly higher than ordinary patients. Dipeptidyl peptidase-4 (DPP4) is one of the functional receptor of human coronavirus. Exploring the relationship between diabetes mellitus targets and DPP4 is particularly important for the management of patients with diabetes and COVID-19. We intend to study the protein interaction through the protein interaction network in order to find a new clue for the management of patients with diabetes with COVID-19. Diabetes mellitus targets were obtained from GeneCards database. Targets with a relevance score exceeding 20 were included, and DPP4 protein was added manually. The initial protein interaction network was obtained through

SUBMITTER: Gao Q 

PROVIDER: S-EPMC8741798 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature