Ontology highlight
ABSTRACT:
SUBMITTER: Guo Z
PROVIDER: S-EPMC8741837 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Guo Zhen Z Tuo Hu H Tang Nan N Liu Fang-Yuan FY Ma Shu-Qing SQ An Peng P Yang Dan D Wang Min-Yu MY Fan Di D Yang Zheng Z Tang Qi-Zhu QZ
International journal of biological sciences 20220101 2
Diabetic cardiomyopathy (DCM) is associated with oxidative stress and augmented inflammation in the heart. Neuraminidases (NEU) 1 has initially been described as a lysosomal protein which plays a role in the catabolism of glycosylated proteins. We investigated the role of NEU1 in the myocardium in diabetic heart. Streptozotocin (STZ) was injected intraperitoneally to induce diabetes in mice. Neonatal rat ventricular myocytes (NRVMs) were used to verify the effect of shNEU1 <i>in vitro</i>. NEU1 ...[more]