High BRCA1 gene expression increases the risk of early distant metastasis in ER⁺ breast cancers.

ABSTRACT: Although the function of the BRCA1 gene has been extensively studied, the relationship between BRCA1 gene expression and tumor aggressiveness remains controversial in sporadic breast cancers. Because the BRCA1 protein is known to regulate estrogen signaling, we selected microarray data of ER⁺ breast cancers from the GEO public repository to resolve previous conflicting findings. The BRCA1 gene expression level in highly proliferative luminal B tumors was shown to be higher than that in luminal A tumors. Survival analysis using a cure model indicated that patients of early ER⁺ breast cancers with high BRCA1 expression developed rapid distant metastasis. In addition, the proliferation marker genes MKI67 and PCNA, which are characteristic of aggressive tumors, were also

SUBMITTER: Chang HJ 

PROVIDER: S-EPMC8741892 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature