Intravital microscopic observation of the microvasculature during hemodialysis in healthy rats.

ABSTRACT: Hemodialysis (HD) provides life-saving treatment for kidney failure. Patient mortality is extremely high, with cardiovascular disease (CVD) being the leading cause of death. This results from both a high underlying burden of cardiovascular disease, as well as additional physiological stress from the HD procedure itself. Clinical observations indicate that HD is associated with microvascular dysfunction (MD), underlining the need for a fundamental pathophysiological assessment of the microcirculatory consequences of HD. We therefore successfully developed an experimental small animal model, that allows for a simultaneous real-time assessment of the microvasculature. Using in-house built ultra-low surface area dialyzers and miniaturized extracorporeal circuit, we successfully dialyzed male W

SUBMITTER: Janssen BGH 

PROVIDER: S-EPMC8741960 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature